What we have here is an herb that is loaded with phyto-oestrogenic chemicals, the most important of which, when compared to other herbs, are the isoflavones. Trifolium contains the four main isoflavone phyto-oestrogens. Other herbs don't have all of them. This herb (or other phyto-oestrogen sources herbal or dietary) should be commenced at the first sign of any menopausal symptoms. Indeed, women are particularly well advised to make sure that there are sources of phyto-oestrogens such as beans & peas or soya in their diets all the time. In fact, phyto-oestrogens are absorbed better if you have a healthy gut flora. You can therefore take an acidophilus supplement along with the phyto-oestrogens to optimise their absorption. Men should also remember that the isoflavones are good for treating prostate enlargement also.